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. Author manuscript; available in PMC: 2010 Aug 25.
Published in final edited form as: Nature. 2010 Feb 25;463(7284):1092–1095. doi: 10.1038/nature08762

Figure 1. PMK-1 p38 MAPK-dependent activation of the IRE-1-XBP-1-dependent UPR by P. aeruginosa infection.

Figure 1

(a) Fluorescence and DIC microscopy of WT and mutant larvae carrying the Phsp-4∷GFP(zcIs4) transgene 24 h after egg lay on indicated treatments (Scale bar = 100μm). (b) qRT-PCR of endogenous hsp-4 mRNA levels. (c) qRT-PCR analysis of total and spliced xbp-1 mRNA levels. Values represent fold change relative to WT on OP50 ± s.e.m. (n = 4 independent experiments, *P < 0.05 and ***P < 0.001, two-way ANOVA with Bonferroni post test).