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. Author manuscript; available in PMC: 2010 Aug 25.
Published in final edited form as: Nature. 2010 Feb 25;463(7284):1092–1095. doi: 10.1038/nature08762

Figure 4. XBP-1 is required for development and survival during pathogen-independent constitutive activation of PMK-1.

Figure 4

(a) Fluorescence and DIC microscopy of WT and xbp-1 larvae carrying the Phsp-4∷GFP(zcIs4) transgene, which have been treated with control (empty vector) or vhp-1 RNAi, 24 h after egg lay. (b) Development to the L4 larval stage or older after 3 d at 25° C of WT, xbp-1, and xbp-1;pmk-1 mutants that have been subjected to RNAi of vhp-1 and propagated on E. coli OP50.

Plotted is mean ± s.e.m (n = 3 independent experiments, ***P < 0.001, two-way ANOVA with Bonferroni post test).