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. Author manuscript; available in PMC: 2010 Mar 8.
Published in final edited form as: J Immunol. 2008 Mar 15;180(6):4218–4226. doi: 10.4049/jimmunol.180.6.4218

FIGURE 8.

FIGURE 8

Effect of Pik3r1 or p85α deficiency on inflammation and coagulation in endotoxemic mice. A, Genotyping of blood cells from WT mice containing either WT or Pik3r1−/− bone marrow (4 mice per group). B, p85α protein levels in blood cells isolated from WT mice containing either WT or Pik3r1−/− bone marrow. WT mice with either WT or Pik3r1−/− bone marrow were injected with LPS (5 mg/kg) and the plasma levels of TNF-α (C), IL-6 (D), and TAT (E) (8 h) were determined. n = 20 –30 mice for each group. WT and p85α−/− mice were injected with LPS (5 mg/kg) and the plasma levels of TNF-α (F), IL-6 (G), and TAT (H) (8 h) were determined. n = 10 mice for each group. Data are expressed as mean ± SEM.*, p < 0.05.