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. 2009 Jul 21;15(1):80–92. doi: 10.1038/mp.2009.67

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Copyright 2010, Nature Publishing Group

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Behavioral analysis of rats subjected to brain-derived neurotrophic factor (BDNF) knockdown (KD) in the CA3. Lentiviral vector (LV)-shBDNF (knockdown) or LV-shSCR (control) constructs were injected into the CA3 of mature rats. The battery of behavioral tests was initiated 3 weeks after recovery from the surgery and the following parameters were measured: sucrose preference (a), activity in a modified forced swim test (FST) (b), home-cage locomotion (c), exploration of a novel environment (d), latency to reach the platform in the water maze task (e) and percent of time spent at the target quadrant during the probe trial in the water maze task (f), as described in Figure 2. Values are mean±s.e.m. (n=8 per group).