Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 May 19;15(2):154–165. doi: 10.1038/mp.2009.46

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright 2010, Nature Publishing Group

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

PMC Copyright notice

Effects of a corticotropin-releasing hormone receptor type 1 (CRHR1) antagonist, DMP696, on recovery sleep after sleep deprivation (SD) in CRH-COE-Nes mice. Data points ±s.e.m. indicate 1 h averages in time spent in non-rapid eye movement (non-REM) sleep (nonREMS) and REM sleep (REMS) during 7 h after 6-h SD initiated at Zeitgeber time (ZT)0. Animals received either vehicle or DMP696 per os at ZT5, at 1 h before the end of SD. Open and filled symbols indicate sleep changes after vehicle and antagonist treatment, respectively. Shaded area indicates the dark period. Numbers in brackets represent the sample size. Two-way analysis of variance for treatment effect between each genotype; CRH-COE^con-Nes for REM sleep F(1, 132)=4.55, P<0.05; CRH-COE^het-Nes for non-REM sleep F(1, 120)=5.68, P<0.05, for REM sleep F(1, 120)=8.19, P<0.01; CRH-COE^hom-Nes for non-REM sleep F(1, 132)=5.90, P<0.05, for REM sleep F(1, 132)=8.62, P<0.01. ^* denotes statistical significance in treatment (P<0.05).