Table 1.

Single nucleotide polymorphisms (SNPs) detected in seven candidate genes for depression in Mexican-Americans

		SNP type
Gene (Location)	SNPa	Downstream	3′ UTR	Intronic	SYN	NS	5′ UTR	Upstream	All	Sequence screened (kb)	Nucleotide diversity (s.d.) × 10−4
CREB1 (2q34)	New	2	5	5	0	0	0	0	12	7.5	3.2 (0.9)
	dbSNP	1	2	2	1	0	0	0	6
	Total	3	7	7	1	0	0	0	18
SLC6A3 (5p15.3)	New	0	2	6	2	1	0	7	18	12.3	5.3 (1.2)
	dbSNP	0	7	10	5	1	0	7	30
	Total	0	9	16	7	2	0	14	48
ABCB1 (7q21.1)	New	0	0	20	1	3	4	0	28	28.5	3.8 (0.8)
	dbSNP	0	4	37	2	5	4	1	53
	Total	0	4	57	3	8	8	1	81
NTRK2 (9q22.1)	New	0	43	10	2	2	0	0	57	23.6	5.1 (1.0)
	dbSNP	0	24	6	2	0	0	0	32
	Total	0	67	16	4	2	0	0	89
SLC6A2 (16q12.2)	New	0	4	10	2	1	1	11	29	13.3	5.6 (1.2)
	dbSNP	0	4	9	2	2	0	9	26
	Total	0	8	19	4	3	1	20	55
SLC6A4 (17q11.1-q12)	New	5	4	23	0	4	1	0	37	12.5	7.8 (1.6)
	dbSNP	4	1	23	4	1	2	0	35
	Total	9	5	46	4	5	3	0	72
CRHR1 (17q12-q22)	New	2	8	12	0	1	0	0	23	6.9	10.9 (2.4)
	dbSNP	1	12	16	3	1	0	0	33
	Total	3	20	28	3	2	0	0	56
All seven genes	New	9	66	86	7	12	6	18	204	104.5	5.4 (1.0)
	dbSNP	6	54	103	19	10	6	17	215
	Total	15	120	189	26	22	12	35	419

Abbreviations: ABCB1, ATP-binding cassette subfamily B member 1; CREB1, cyclic AMP-responsive element binding protein 1; CRHR1, corticotropin-releasing hormone receptor 1; NS, non-synonymous; SYN, synonymous; NTRK2, neurotrophic tyrosine kinase type 2 receptor; UTR, untranslated region.

^aNew: not reported in NCBI dbSNP database as of 30 June 2008.