Table 2.

Polymorphisms associated with depression in Mexican-Americans

						Risk allele frequency			P
Gene	SNP	Chromosome	Position	SNP type	Risk/non- risk allele	Case	Control	ORa (95% CI)	Allelic	Genotypic
CREB1	rs3730276	2	208140591	INT	A/G	0.998	0.977	11.45 (1.46–89.77)	0.004	0.003
SLC6A3	rs8179029	5	1462985	INT	C/T	0.910	0.856	1.71 (1.12–2.58)	0.02	0.02
	rs2550936	5	1464256	INT	A/C	0.839	0.799	1.31 (0.94–1.83)	0.13	0.004
ABCB1	rs4728697	7	86986874	INT	A/G	0.060	0.028	2.24 (1.18–4.28)	0.01	0.02
	rs2032583	7	86998497	INT	A/G	0.936	0.899	1.64 (1.04–2.59)	0.04	0.10
	rs58898486	7	87063142	INT	G/T	0.998	0.984	8.40 (1.05–67.39)	0.02	0.02
NTRK2	rs7020204	9	86616007	INT, 3′ UTR	C/T	0.899	0.850	1.57 (1.07–2.32)	0.02	0.05
	rs2013566	9	86616118	INT, 3′ UTR	A/G	0.876	0.828	1.47 (1.02–2.10)	0.04	0.13
SLC6A4	rs7224199	17	25547852	Downstream	G/T	0.411	0.369	1.19 (0.92–1.55)	0.19	0.004
	rs3813034	17	25548930	Downstream	A/C	0.454	0.399	1.25 (0.98–1.60)	0.08	0.040
	rs140701	17	25562658	INT	C/T	0.454	0.400	1.25 (0.97–1.61)	0.09	0.01
	rs7212502	17	25573328	INT	A/G	1.000	0.987	8.56 (1.23–∞)	0.01	0.01
	rs28914831	17	25573988	5′ UTR	G/T	1.000	0.988	8.37 (1.20–∞)	0.02	0.01
	rs2066713	17	25575791	INT	A/G	0.329	0.263	1.37 (1.04–1.80)	0.03	0.004
	NT_010799.14_3288789	17	25575922	INT	C/G	1.000	0.988	8.63 (1.24–∞)	0.01	0.01
	rs56355214	17	25576325	INT	G/A	1.000	0.988	8.47 (1.22–∞)	0.01	0.01

Abbreviations: ABCB1, ATP-binding cassette subfamily B member 1; CI, confidence interval; CREB1, cyclic AMP-responsive element binding protein 1; INT, Intronic; NTRK2, neurotrophic tyrosine kinase type 2 receptor; OR, odds ratio; SNP, single nucleotide polymorphism; UTR, untranslated region.

^aOR: calculation based on allele count and 95% CI based on exact logistic model when one cell count is 0.