Table 3.
Polymorphisms associated with remission after 8-week antidepressant treatment with desipramine or fluoxetine
| Better allele frequency | Fisher's exact P | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Medication | Gene | SNP | Chromo- some | Position | SNP type | Better/poor response allele | Remitter | Non-remitter | ORa (95% CI) | Allelic | Genotypic |
| Desipramine or fluoxetine (N=142) | ABCB1 | rs3842 | 7 | 86971302 | 3′ UTR | C/T | 0.203 | 0.094 | 2.44 (1.14–5.24) | 0.02 | 0.11 |
| rs17064 | 7 | 86971406 | 3′ UTR | A/T | 0.100 | 0.028 | 3.81 (1.08–13.5) | 0.03 | 0.11 | ||
| NTRK2 | rs45596934 | 9 | 86618439 | INT, 3′ UTR | A/G | 0.171 | 0.123 | 1.47 (0.74–2.94) | 0.31 | 0.002 | |
| NT_023935.17_16593339 | 9 | 86618627 | INT, 3′ UTR | T/C | 0.177 | 0.123 | 1.53 (0.77–3.05) | 0.24 | 0.002 | ||
| NT_023935.17_16593340 | 9 | 86618628 | INT, 3′ UTR | G/A | 0.181 | 0.123 | 1.58 (0.79–3.15) | 0.24 | 0.001 | ||
| rs1624327 | 9 | 86619110 | INT, 3′ UTR | A/G | 0.321 | 0.224 | 1.64 (0.95–2.83) | 0.08 | 0.021 | ||
| NT_023935.17_16651920 | 9 | 86677208 | INT, 3′ UTR | G/C | 0.961 | 0.880 | 3.35 (1.14–9.86) | 0.02 | 0.05 | ||
| rs2289658 | 9 | 86753190 | INT, splice site | T/C | 0.885 | 0.778 | 2.19 (1.12–4.28) | 0.03 | 0.05 | ||
| Desipramine (N=68) | ABCB1 | rs17064 | 7 | 86971406 | 3′ UTR | A/T | 0.132 | 0.018 | 8.39 (1.03–68.4) | 0.02 | 0.14 |
| NTRK2 | NT_023935.17_16593339 | 9 | 86618627 | INT, 3′ UTR | T/C | 0.157 | 0.113 | 1.47 (0.53–4.05) | 0.61 | 0.03 | |
| NT_023935.17_16593340 | 9 | 86618628 | INT, 3′ UTR | G/A | 0.167 | 0.113 | 1.57 (0.57–4.35) | 0.45 | 0.02 | ||
| rs11140793 | 9 | 86681300 | INT, 3′ UTR | A/C | 0.882 | 0.726 | 2.83 (1.12–7.14) | 0.03 | 0.05 | ||
| rs2289658 | 9 | 86753190 | INT, splice site | T/C | 0.909 | 0.742 | 3.48 (1.26–9.59) | 0.02 | 0.04 | ||
| rs2289657 | 9 | 86753280 | SYN | C/A | 0.955 | 0.823 | 4.53 (1.20–17.1) | 0.02 | 0.04 | ||
| rs56142442 | 9 | 86826085 | SYN | C/T | 0.957 | 0.906 | 2.31 (0.55–9.65) | 0.31 | 0.05 | ||
| SLC6A2 | rs5564 | 16 | 54283476 | INT | G/A | 0.141 | 0.000 | 11.92 (1.81–∞) | 0.004 | 0.04 | |
| Fluoxetine (N=74) | ABCB1 | rs1128503 | 7 | 87017537 | SYN | G/A | 0.522 | 0.304 | 2.49 (1.18–5.30) | 0.02 | 0.05 |
| rs10276036 | 7 | 87018134 | INT | T/C | 0.550 | 0.320 | 2.59 (1.24–5.44) | 0.01 | 0.04 | ||
| rs2235020 | 7 | 87037201 | INT | T/A | 0.539 | 0.318 | 2.50 (1.15–5.43) | 0.02 | 0.09 | ||
| NTRK2 | rs1624327 | 9 | 86619110 | INT, 3′ UTR | A/G | 0.348 | 0.212 | 1.99 (0.90–4.39) | 0.09 | 0.04 | |
| NT_023935.17_16651920 | 9 | 86677208 | INT, 3′ UTR | G/C | 0.972 | 0.864 | 5.52 (1.06–28.7) | 0.05 | 0.04 | ||
| SLC6A2 | rs1362621 | 16 | 54245985 | Upstream | A/G | 0.872 | 0.731 | 2.52 (1.06–5.96) | 0.04 | 0.03 | |
Abbreviations: ABCB1, ATP-binding cassette subfamily B member 1; CI, confidence interval; INT, intronic; NTRK2, neurotrophic tyrosine kinase type 2 receptor; OR, odds ratio; SNP, single nucleotide polymorphism; UTR, untranslated region; SYN, synonymous.
a
OR: calculation based on allele count and 95% CI based on exact logistic model when one cell count is 0.