Table 4.
Polymorphisms associated with relative reduction of HAM-D21 score after 8-week antidepressant treatment with desipramine or fluoxetine
| Medication | Gene | SNP | Chromo- some | Position | SNP type | Genotype | N | Mean (s.d.) | Deltaa (95% CI) | Pb | FDR_BHc |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Desipramine or fluoxetine | ABCB1 | rs2214103 | 7 | 87062884 | INT | CC | 132 | 64.26 (21.35) | 21.45 (5.29–37.61) | 0.01 | 0.72 |
| CG | 8 | 46.44 (32.92) | |||||||||
| NTRK2 | rs9969765 | 9 | 86679605 | INT, 3′ UTR | CC | 46 | 69.48 (19.13) | 10.96 (3.11–18.81) | 0.007 | 0.72 | |
| GG/CG | 87 | 58.79 (23.81) | |||||||||
| rs2289657 | 9 | 86753280 | SYN | CC | 106 | 65.38 (20.35) | 12.74 (3.32–22.15) | 0.009 | 0.72 | ||
| AA/AC | 26 | 52.48 (29.11) | |||||||||
| SLC6A2 | NT_010498.15_9300464 | 16 | 54243766 | Upstream | TG | 15 | 77.25 (21.72) | 18.49 (6.60–30.39) | 0.003 | 0.72 | |
| TT | 121 | 60.69 (22.06) | |||||||||
| Desipramine | SLC6A3 | rs8179029 | 5 | 1462985 | INT | CC | 54 | 61.32 (20.05) | 29.79 (9.04–50.54) | 0.007 | 0.56 |
| TT/TC | 6 | 27.05 (39.26) | |||||||||
| NTRK2 | rs7038236 | 9 | 86678222 | INT, 3′ UTR | CC | 37 | 63.52 (18.98) | 16.97 (4.73–29.22) | 0.009 | 0.56 | |
| AA/AC | 18 | 48.02 (24.77) | |||||||||
| rs11140793 | 9 | 86681300 | INT, 3′ UTR | AA | 43 | 62.71 (23.47) | 18.30 (5.74–30.86) | 0.006 | 0.56 | ||
| CC/AC | 22 | 46.39 (23.30) | |||||||||
| rs2289658 | 9 | 86753190 | INT, splice site | TT | 44 | 62.94 (20.19) | 18.00 (5.32–30.69) | 0.007 | 0.56 | ||
| CC/TC | 20 | 43.57 (27.86) | |||||||||
| rs2289657 | 9 | 86753280 | SYN | CC | 51 | 62.11 (19.93) | 26.83 (13.39–40.27) | 0.0002 | 0.05 | ||
| AA/AC | 13 | 36.40 (29.89) | |||||||||
| rs56142442 | 9 | 86826085 | SYN | CC | 59 | 60.70 (19.89) | 33.17 (17.15–49.19) | 0.0001 | 0.05 | ||
| TT/TC | 8 | 28.92 (34.90) | |||||||||
| Fluoxetine | SLC6A2 | NT_010498.15_9300464 | 16 | 54243766 | Upstream | TG | 10 | 85.09 (13.13) | 20.55 (8.23–32.87) | 0.002 | 0.46 |
| TT | 60 | 65.69 (18.37) | |||||||||
| rs4783899 | 16 | 54244713 | Upstream | TT | 24 | 76.99 (15.15) | 15.02 (5.37–24.68) | 0.003 | 0.47 | ||
| GG/TG | 48 | 64.22 (20.09) |
Abbreviations: ABCB1, ATP-binding cassette subfamily B member 1; CI, confidence interval; HAM-D21, 21-item Hamilton Depression Rating Scale; INT, intronic; NTRK2, neurotrophic tyrosine kinase type 2 receptor; SNP, single nucleotide polymorphism; UTR, untranslated region; SYN, synonymous.
a
Delta: adjusted mean difference in relative reduction of HAM-D21 score.
b
P: based on general linear model after controlling for age, gender and baseline HAM-D21 score.
c
Benjamini-Hochberg false discovery rate after correcting for multiple testing.