Table 6.

Haplotypes associated with relative reduction of HAM-D21 score after 8-week antidepressant treatment

Medication	Gene	Block no.	Haplotypea	N	βb	R2 c	t	P
Desipramine or fluoxetine	SLC6A3	Block 1	CGCGAAGT	133	40.95	0.07	3.14	0.002
		Block 1	CGTGCGGT	133	17.01	0.05	2.69	0.008
	ABCB1	Block 3	TCTTACCGATCG	141	27.17	0.05	2.58	0.01
	NTRK2	Block 2	GCACGCCATTGGCAC	140	−5.85	0.03	−2.20	0.03
		Block 3	CAG	132	14.58	0.07	3.16	0.002
		Block 3	TCG	132	−7.49	0.04	−2.35	0.02
		Block 4	CA	134	−11.22	0.04	−2.36	0.02
	SLC6A2	Block 1	GATGAT	140	−15.88	0.04	−2.46	0.01
		Block 1	TAGGGT	140	10.00	0.03	2.10	0.04
Desipramine	SLC6A3	Block 1	CGTGCGGT	65	36.51	0.15	3.29	0.002
		Block 1	CGCGAGGT	65	−15.77	0.12	−2.99	0.004
	NTRK2	Block 2	GAACCCGCTCGGTAC	66	13.69	0.09	2.47	0.02
		Block 2	GCACGCCATTGGCAC	66	−9.68	0.08	−2.30	0.02
		Block 3	CAG	64	24.02	0.20	3.90	0.0002
		Block 3	TCG	64	−11.55	0.09	−2.49	0.02
		Block 4	CA	65	−20.49	0.15	−3.29	0.002
		Block 4	TA	65	22.05	0.13	3.02	0.004
	SLC6A4	Block 1	GAGA	67	10.65	0.08	2.37	0.02
Fluoxetine	NTRK2	Block 2	CCACCCCACCATCTC	72	14.21	0.06	2.16	0.03
	SLC6A2	Block 1	GATGAT	73	−18.92	0.10	−2.88	0.005
		Block 1	TAGGGT	73	14.54	0.10	2.73	0.008
		Block 2	GT	67	−13.66	0.06	−2.03	0.05
	SLC6A4	Block 1	GAAA	74	28.05	0.06	2.08	0.04

Abbreviation: ABCB1, ATP-binding cassette subfamily B member 1; HAM-D21, 21-item Hamilton Depression Rating Scale; NTRK2, neurotrophic tyrosine kinase type 2 receptor; SNP, single nucleotide polymorphism.

^aLetters with underline indicate the SNPs also showing an association with a nominal P<0.05 in the corresponding SNP-based analysis.

^bβ: regression coefficient after controlling for age, gender and baseline HAM-D21 score.

^cR²: proportion variance explained.