Table 4.
Phenotypic combinations of HLA-A*02 and HLA-Cw*05 in MS patients and controls
| A*02 | Cw*05 | Sample | Frequency | P-value | OR (95% CI) | |
|---|---|---|---|---|---|---|
| Cases | Controls | |||||
| Total | N=1273 | N=1075 | ||||
| − | − | 0.599 | 0.513 | 2.4 × 10−5 | 1.42 (1.21–1.68) | |
| + | + | 0.031 | 0.078 | 4.1 × 10−7 | 0.38 (0.26–0.56) | |
| + | − | 0.299 | 0.370 | 2.8 × 10−4 | 0.73 (0.61–0.86) | |
| − | + | 0.070 | 0.039 | 0.001 | 1.85 (1.27–2.69) | |
| DR15 negative | N=883 | N=935 | ||||
| − | − | 0.589 | 0.498 | 1.1 × 10−4 | 1.44 (1.20–1.73) | |
| + | + | 0.031 | 0.081 | 1.8 × 10−6 | 0.36 (0.23–0.56) | |
| + | − | 0.303 | 0.383 | 3.6 × 10−4 | 0.70 (0.58–0.85) | |
| − | + | 0.077 | 0.038 | 2.4 × 10−4 | 2.15 (1.41–3.26) | |
Abbreviations: CI, confidence intervals; MS, multiple sclerosis; OR, odds ratio.