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Tumor-specific replication, biodistribution and serum granulocyte-monocyte colony-stimulating factor (GM-CSF) protein expression after i.v. administration of JX-963 in the VX2 liver tumor model. (a) Biodistribution of vvDD and JX-963 in tumors vs normal organs over time following intravenous injection. (b) hGM-CSF serum concentrations over time following intravenous injection of JX-963 in tumor-free and VX2-bearing rabbits.
