Figure 5.

Development of the ovary in Ad-LacZ control animal (A) compared with Ad-FSHR treated animal (B). Both the total number of follicles and the number of antral follicles are significantly higher in Ad-FSHR treated than Ad-LacZ control group. Histological evaluation showed on average 26 ± 4 follicles/ovary in treated group with 8 ± 2 follicles at the antral stage compared with only 5 ± 2 with zero follicles at antral stage in Ad-LacZ control mice. Photos were taken at the same magnification (×600); (C) is an area from treated ovary (inset marked—c) shown at 10× higher magnification; (D) Mean number of follicles at different time points of experiments. As shown the total numbers of follicles are significantly increased in treated versus control animals (P < 0.02). The most number of follicle increase observed at 8 weeks of treatment.