Table 1.
Patient Demographics and Clinical Characteristics of NYU Validation Cohort and Comparison by Time of Initial Postsurgery OPN Measurement
| Variable | NYU Validation Cohort (n = 96) | Postsurgery OPN Measured at ≤ 6 Weeks (n = 60) | Postsurgery OPN Measured at > 6 Weeks (n = 36) | P (< 6 v > 6 weeks) |
|---|---|---|---|---|
| Presurgery OPN | ||||
| Median | 324 | 322 | 327 | .924 |
| Range | 25-918 | 25-842 | 80-918 | |
| Postsurgery OPN | ||||
| Median | 256 | 304 | 177 | .003 |
| Range | 7-1051 | 7-967 | 25-1051 | |
| Age | ||||
| Median | 68.5 | 67.6 | 69.9 | .874 |
| Range | 40-88 | 41-84 | 40-88 | |
| Sex | ||||
| Female | 57 | 36 | 21 | .750 |
| Male | 39 | 24 | 15 | |
| Tobacco use | ||||
| Never | 15 | 11 | 4 | .680 |
| Former | 69 | 40 | 29 | |
| Current | 12 | 9 | 3 | |
| Pack years | ||||
| Median | 38 | 38 | 38 | .983 |
| Range | 0-160 | 0-120 | 0-160 | |
| COPD | ||||
| Yes | 20 | 16 | 4 | .070 |
| No | 76 | 44 | 32 | |
| Diabetes mellitus | ||||
| Yes | 9 | 5 | 4 | .675 |
| No | 87 | 55 | 32 | |
| Albumin | ||||
| Median | 4.3 | 4.3 | 4.3 | .364 |
| Range | 2.9-5.0 | 3.6-5.0 | 2.9-4.9 | |
| Creatinine | ||||
| Median | 0.9 | 1.0 | 0.9 | .559 |
| Range | 0.3-6.0 | 0.3-6.0 | 0.5-1.9 | |
| Histology | ||||
| Adeno | 81 | 49 | 32 | .223 |
| Squamous | 14 | 10 | 4 | |
| NOS | 1 | 1 | 0 | |
| Lymphovascular invasion | ||||
| Present | 68 | 15 | 8 | .770 |
| Absent | 23 | 42 | 26 | |
| NR | 5 | 3 | 2 | |
| p stage | ||||
| IA | 57 | 35 | 22 | .987 |
| IB | 16 | 9 | 7 | |
| IIA | 9 | 5 | 4 | |
| IIB | 5 | 4 | 1 | |
| IIIA | 6 | 4 | 2 | |
| IV | 1 | 1 | 0 | |
| Type of resection | ||||
| Wedge | 20 | 12 | 8 | .784 |
| Segmentectomy | 14 | 12 | 2 | |
| Lobectomy | 58 | 33 | 25 | |
| Bilobectomy | 3 | 2 | 1 | |
| Pneumonectomy | 1 | 1 | 0 | |
| Mode of resection | ||||
| VATS | 65 | 41 | 24 | .867 |
| Open | 31 | 19 | 12 |
Abbreviations: NYU, New York University; OPN, osteopontin; COPD, chronic obstructive pulmonary disease; adeno, adenocarcinoma; squamous, squamous cell carcinoma; NOS, not otherwise specified; NR, not recorded; p stage, pathologic stage by the 7th edition TNM staging criteria; VATS, video-assisted thoracic surgery; open, open thoracotomy.