Table 2.
Univariate and Multivariate Analysis Conducted for Pre-Operative OPN and Post-Operative OPN
| Variable | Pre-Operative OPN (n = 96) |
Post-Operative OPN (N = 73) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Univariate |
Multivariate |
Univariate |
Multivariate |
|||||||
| RR | 95% CI | P | RR | P | RR | 95% CI | P | RR | P | |
| Age | 0.023 | −25 to 130 | .075 | 0.002 | .640 | 0.030 | −46 to 118 | .141 | ||
| Sex | 0.010 | −69 to 91 | .784 | 0.026 | −92 to 73 | .825 | ||||
| Smoker (ever v never) | 0.011 | −49 to 158 | .304 | 0.002 | −134 to 95 | .730 | ||||
| Albumin | 0.105 | 44 to 194 | .001* | 0.060 | .012* | 0.014 | 0.03 to 161 | .023* | 0.001 | .866 |
| Creatinine | 0.091 | 4 to 164 | .003* | 0.068 | .006* | 0.073 | −151 to 22 | .749 | ||
| HTN | 0.040 | 0.8-to 153 | .003* | 0.020* | .160 | 0.024 | −73 to 91 | .841 | ||
| CAD | 0.068 | 28 to 207 | .010* | 0.025* | .120 | 0.046 | −191 to 6.9 | .068 | 0.006 | .529 |
| VATS v open | 0.004 | −59 to 108 | .557 | 0.077 | 18 to 181 | .017* | 0.080 | .016* | ||
| p stage (IASLC) | 0.010 | .909 | 0.010 | .942 | ||||||
| LV invasion | 0.010 | −188 to 49 | .348 | 0.014 | −147 to 49 | .322 | ||||
| Presurgery OPN | NA | NA | NA | NA | NA | .067 | .001* | 0.059 | .066 | |
Abbreviations: OPN, osteopontin; RR, relative risk; HTN, hypertension; CAD, coronary artery disease; VATS, video-assisted thoracic surgery; open, open thoracotomy; p stage, pathologic stage by the 7th edition TNM staging criteria; IASLC, International Association for the Study of Lung Cancer 2009 Lung Cancer Staging System; LV, lymphovascular; NA, not applicable.
*
Significant.