FIG. 1.
Non-obese diabetic severe combined immunodeficient (NOD-SCID) mice exhibited improved open-field locomotor recovery after contusion spinal cord injury (SCI), while C57BL/6 and BUB/BnJ mice did not. Two-way ANOVA comparison of BMS locomotor performance (sex and time) was performed for each strain. In each case, there were no sex differences in locomotor recovery. Thus the groups were collapsed within strains to increase power. Repeated-measures ANOVA of the collapsed groups showed significant main effects of strain (p < 0.0001), time (p < 0.0001), and strain × time interaction. Bonferroni post-hoc tests of the collapsed groups showed that NOD-SCID mice outperformed both C57BL/6 (***p < 0.001) and BUB/BnJ mice at all post-injury time points (#p < 0.05, ##p < 0.01). C57BL/6 and BUB/BnJ mice did not differ from each other at any time point (ANOVA, analysis of variance; BMS, Basso mouse scale).