Table 1.
Genes Positively Correlated With Plasma Estradiol Concentration
| Spearman Rank | Gene Symbol | Genbank Accession No. | Spearman Correlation Coefficient | Parametric P | Known Estrogenic Function |
|---|---|---|---|---|---|
| 1 | TFF1 | NM_003225 | 0.469 | 7.00E-07 | Estradiol-responsive gene in vitro and in vivo10,22,23 |
| 2 | CAPN2 | NM_001748 | 0.430 | 6.40E-06 | |
| 3 | CAPN9 | NM_016452 | 0.378 | .73E-05 | |
| 4 | UNG2 | NM_021147 | 0.374 | .0001027 | |
| 5 | GREB1 | NM_148903 | 0.360 | .0001955 | Estradiol-responsive gene in vitro and in vivo10,22–24 |
| 6 | RAGE | NM_014226 | 0.357 | .0002178 | Estradiol-responsive gene in vitro25 |
| 7 | BTD | NM_000060 | 0.346 | .000348 | |
| 8 | VN1R2 | NM_173856 | 0.344 | .000378 | |
| 9 | TLE1 | NM_005077 | 0.337 | .0005016 | |
| 10 | SPG3A | NM_181598 | 0.336 | .0005227 | |
| 14 | AZGP1 | NM_001185 | 0.329 | .0006986 | Estradiol-responsive gene in vivo22 |
| 31 | PDZK1 | XM_943050 | 0.310 | .0014502 | Estradiol-responsive gene in vitro and in vivo10,22,23 |
| 57 | SERPINA3 | NM_001085 | 0.298 | .0022427 | Estradiol-responsive gene in vivo23 |
| 59 | IRS1 | NM_005544 | 0.297 | .0022581 | Estradiol-responsive gene in vitro26 |
| 75 | TFF2 | NM_005423 | 0.290 | .0029109 | Estradiol-responsive gene in GI tract27 |
| 85 | PGR | NM_000926 | 0.286 | .0034066 | Established measure of estrogenicity3 |
| 119 | TFF3 | NM_003226 | 0.276 | .0047773 | Estradiol-responsive gene in vivo23 |
NOTE. Ranked according to Spearman correlation. The 10 most strongly correlated genes are shown together with genes known to be associated with estrogen signaling with P < .005.