Table 1.

Patient Characteristics (N = 266)

Characteristic	Enzastaurin (n = 174)		Lomustine (n = 92)
	No.	%	No.	%
Sex
Male	116	66.7	56	60.9
Female	58	33.3	36	39.1
Age, years
< 50	44	25.3	28	30.4
≥ 50	130	74.7	64	69.6
Karnofsky performance status*
Low, 70 or 80	83	47.7	46	50.0
High, 90 or 100	90	51.7	45	48.9
Pathologic diagnosis*
Glioblastoma	171	98.8	89	97.8
Gliosarcoma	2	1.2	2	2.2
Time from diagnosis to random assignment, months
Median	10.1		12.1
Range	0.9-51.5		4.4-92.0
Disease recurrence†
First	129	74.1	70	76.9
Second	45	25.9	21	23.1
History of seizures
Yes	84	48.3	45	48.9
No	90	51.7	47	51.1
Prior therapies
Surgery	174	100	91	98.9
Radiotherapy	174	100	91	98.9
Systemic therapy	173	99.4	90	97.8
Corticosteroid	92	52.9	48	52.2
EIAED therapy	54	31.0	25	27.2

Abbreviation: EIAED, enzyme-inducing antiepileptic drugs.

^*The status of two patients was unknown.

^†Disease recurrence was reported in 91 patients in lomustine arm.