Table 3.

Drug-Related Toxicities^*

Toxicity	Enzastaurin (n = 167)†				Lomustine (n = 84)†
	Grade 2		Grade 3 to 4		Grade 2		Grade 3 to 4
	No.	%	No.	%	No.	%	No.	%
Nonhematologic toxicity
Fatigue	5	3.0	6	3.6	5	6.0	0
Anorexia	2	1.2	0		0		0
Nausea	1	0.6	0		2	2.4	0
GI	2	1.2	0		0		0
Flatulence	2	1.2	0		0		0
Edema	7	4.2	2	1.2	2	2.4	0
Infection	1	0.6	2	1.2	1	1.2	3	3.6
Stomatitis	2	1.2	0		2	2.4	0
Thrombosis	1	0.6	3‡	1.8	0		0
Hematologic toxicity
Anemia	1	0.6	0		3	3.6	2	2.4
Neutropenia	1	0.6	0		4	4.8	17	20.2
Thrombocytopenia	4	2.4	1	0.6	9	10.7	21	25.0
Lymphopenia	0		0		2	2.4	0
Leukopenia	2	1.2	0		3	3.6	6	7.1

^*Grade 2 or grade 3 to 4 toxicities in one or more patient in either arm.

^†15 patients (seven assigned to enzastaurin, eight assigned to lomustine) discontinued before receiving treatment and were not included in the safety analysis.

^‡Two patients receiving enzastaurin had grade 4 thrombosis.