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ADAM-17 phosphorylation is ERK dependent. A) PD98059 (PD) inhibits 5-HT-induced ADAM-17 threonine phosphorylation (p-Threonine). B) Phosphorylated ERK interacts with ADAM-17 during 5-HT treatment in mesangial cells. IP: immunoprecipitation. Figure shows one representative experiment out of 3.
