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. Author manuscript; available in PMC: 2010 Mar 8.
Published in final edited form as: Nat Immunol. 2002 Apr 22;3(5):451–456. doi: 10.1038/ni792

Figure 5. Generation of long-lived bone marrow plasma cells.

Figure 5

(a) Mice were immunized with 100 μg of NP36-KLH emulsified in CFA. Mice were killed 68 days after immunization and bone marrow was collected. Bone marrow–derived lymphocytes were assessed for production of total antigen-specific IgG1 by ELISPOT; NP25-BSA was used as a capture antigen. (b) Generation of high-affinity plasma cells in the bone marrow of the same mice used in a. NP4-BSA was used as a capture antigen. Data are expressed as the number of antibody-secreting cells per 106 input cells and are representative of three or more independent experiments.