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CONSORT diagram. (*) Patients who subsequently obtain complete remission (CR)/CR unconfirmed (CRu) receive two additional cycles and follow the schema for CR/CRu. (†) If discontinued per physician discretion where patient is still responding and has not refused follow-up or gone to other treatment, follow in observation. Patients with macroglobulinemia and who obtain a minor response should follow the schema as a partial response (PR). One cycle = 4 weeks. MR, minimal remission.
