Table 2.

All Grade 3 and 4 Toxicities (adverse events at least possibly related) to Everolimus

Toxicity	Grade 3		Grade 4
	No.	%	No.	%
Hematologic
Anemia	8	16	1	2
Leukopenia	8	16	2	4
Neutropenia	6	12	1	2
Thrombocytopenia	6	6	5	10
Infection/febrile neutropenia
Pneumonia	1	2
Upper airway infection	1	2
Sepsis	1	2
Metabolic/laboratory
Hypercholesterolemia	2	4
Hyperglycemia	2	4
Hypertriglyceridemia	1	2
Hypoglycemia	1	2
Hyponatremia	1	2
Pulmonary
Dyspnea	2	4
Pleural effusion with dyspnea	1	2
Constitutional symptoms
Fatigue	4	8	1	2
Gastrointestinal
Diarrhea	3	6
Mucositis, oral ulcers	4	8
Maximum overall grade	21	42	7	14

NOTE. Maximal overall toxicity grade refers to the number of patients that had the respective grade toxicity across all toxicity types.