Table 2.
Response Measured by M Spike and Using IgM Measured by Nephelometry
| Response | M Spike |
IgM by Nephelometry |
||
|---|---|---|---|---|
| No. | % | No. | % | |
| CR | 1 | 3 | 2 | 5 |
| nCR | 1 | 3 | NA | |
| PR | 17 | 46 | 21 | 57 |
| MR | 11 | 30 | 9 | 24 |
| SD | 4 | 11 | 2 | 5 |
| PD | 1 | 3 | 1 | 3 |
| Unevaluable | 2 | 5 | 2 | 5 |
| CR + nCR + PR + MR* | 30 | 81 | 32 | 87 |
| CR + nCR + PR† | 19 | 51 | 23 | 62 |
Abbreviations: IgM, immunoglobulin M; CR, complete remission; nCR, near CR; NA, not applicable; PR, partial remission; MR, minimal response; SD, stable disease; PD, progressive disease.
*
95% exact two-stage CIs for proportion of patients with CR + nCR + PR + MR by M spike is 65 to 92 and with a CR + PR + MR by nephelometry is 71 to 96.
†
95% exact two-stage CIs for proportion of patients with a CR + nCR + PR by M spike is 35 to 69 and with a CR + PR by nephelometry is 45 to 78.