Figure 3.

High- and low-VDR monocyte subpopulations demonstrate unique levels of TLR2, cathelicidin, and CYP24 expression. Our previous finding of the existence of two distinct populations after cholecalciferol therapy prompted us to perform a subanalysis to evaluate the difference in TLR2, cathelicidin, and CYP24 expression within these two monocyte subsets. We found TLR2 expression to be five-fold greater in the high-VDR monocyte subset compared with the low-VDR monocytes (P < 0.001), whereas cathelicidin expression was two-fold greater (P < 0.01) and CYP24 expression was three-fold greater (NS) in the high-VDR monocytes.