Table 2. HLA-DRB1 frequencies (generic DR types) in patients with VKH syndrome compared to patients with SO and to healthy controls.
|
|
VKH patient alleles (2n=188) |
SO patient alleles (2n=78) |
Control subject alleles (2n=224) |
VKH versus controls |
SO versus controls |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Allele | number | % | number | % | number | % | OR | 95% CI | p-value† | OR | 95% CI | p-value† |
|
HLA-DRB1*01 |
4 |
2.1 |
1 |
1.3 |
4 |
1.8 |
1.20 |
0.30–4.85 |
1 |
0.71 |
0.08–6.49 |
1 |
|
HLA-DRB1*03 |
10 |
5.3 |
8 |
10.3 |
12 |
5.4 |
0.99 |
0.42–2.35 |
1 |
2.02 |
0.79–5.14 |
0.18 |
|
HLA-DRB1*04 |
38 |
20.2 |
11 |
14.1 |
23 |
10.3 |
2.21 |
1.27–3.87 |
0.005# |
1.44 |
0.66–3.10 |
0.41 |
|
HLA-DRB1*07 |
30 |
16.0 |
7 |
9.0 |
40 |
17.9 |
0.87 |
0.52–1.47 |
0.69 |
0.45 |
0.19–1.06 |
0.07 |
|
HLA-DRB1*08 |
5 |
2.7 |
7 |
9.0 |
9 |
4.0 |
0.65 |
0.22–1.98 |
0.59 |
2.36 |
0.85–6.56 |
0.14 |
|
HLA-DRB1*09 |
2 |
1.1 |
2 |
2.6 |
0 |
0.0 |
6.02 |
0.29–126 |
0.21 |
14.7 |
0.70–309 |
0.07 |
|
HLA-DRB1*10 |
15 |
8.0 |
9 |
11.5 |
24 |
10.7 |
0.72 |
0.37–1.42 |
0.40 |
1.09 |
0.48–2.45 |
0.84 |
|
HLA-DRB1*11 |
6 |
3.2 |
2 |
2.6 |
5 |
2.2 |
1.44 |
0.43–4.81 |
0.56 |
1.15 |
0.22–6.07 |
1 |
|
HLA-DRB1*12 |
6 |
3.2 |
2 |
2.6 |
12 |
5.4 |
0.58 |
0.21–1.58 |
0.34 |
0.47 |
0.10–2.13 |
0.53 |
|
HLA-DRB1*13 |
16 |
8.5 |
3 |
3.8 |
21 |
9.4 |
0.90 |
0.46–1.78 |
0.86 |
0.39 |
0.11–1.33 |
0.15 |
|
HLA-DRB1*14 |
19 |
10.1 |
4 |
5.1 |
15 |
6.7 |
1.57 |
0.77–3.18 |
0.22 |
0.75 |
0.24–2.34 |
0.79 |
|
HLA-DRB1*15 |
36 |
19.1 |
22 |
28.2 |
59 |
26.3 |
0.66 |
0.41–1.06 |
0.10 |
1.10 |
0.62–1.95 |
0.77 |
| HLA-DRB1*16 | 1 | 0.5 | 0 | 0.0 | 0 | 0.0 | 3.59 | 0.15–88.7 | 0.46 | n.a. | n.a. | n.a. |
The dagger indicates Fisher's exact test. The sharp (hash mark) indicates Bonferroni correction for multiple comparisons pc=0.067 (n=13). n.a. indicates not applicable.