Table 3. Genotypic frequencies of HLA-DRB1 alleles within the DR1 and DR4 specificities.
|
|
VKH patient alleles (2n=188) |
SO patient alleles (2n=78) |
Control subject alleles (2n=224) |
VKH versus controls |
SO versus controls |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Allele | number | % | number | % | number | % | OR | 95% CI | p-value† | OR | 95% CI | p-value† |
|
HLA-DRB1*0101 |
4 |
2.1 |
1 |
1.3 |
4 |
1.8 |
1.20 |
0.30–4.85 |
1 |
0.71 |
0.08–6.49 |
1 |
|
HLA-DRB1*0403 |
18 |
9.6 |
7 |
9.0 |
16 |
7.1 |
1.38 |
0.68–2.78 |
0.38 |
1.28 |
0.51–3.24 |
0.62 |
|
HLA-DRB1*0405 |
10 |
5.3 |
1 |
1.3 |
1 |
0.4 |
12.5 |
1.59–98.8 |
0.003# |
2.90 |
0.18–46.9 |
0.45 |
|
HLA-DRB1*0407 |
1 |
0.5 |
0 |
0.0 |
0 |
0.0 |
3.59 |
0.15–88.7 |
0.46 |
n.a. |
n.a. |
n.a. |
|
HLA-DRB1*0410 |
6 |
3.2 |
2 |
2.6 |
1 |
0.4 |
7.35 |
0.88–61.6 |
0.051 |
5.87 |
0.53–65.6 |
0.17 |
| HLA-DRB1*0405 or *0410 | 16 | 8.5 | 3 | 3.8 | 2 | 0.9 | 10.3 | 2.34–45.5 | <0.001 | 4.44 | 0.73–27.1 | 0.11 |
The dagger indicates Fisher's exact test. The sharp (hash mark) indicates Bonferroni correction for multiple comparisons pc=0.017 (n=5). n.a. indicates not applicable.