Table 2.
Effect of CoQ10 intake on mitochondrial superoxide production, carbonyl content, and activities of oxidoreductases of 25-month-old mice
| Tissue | Diet | Superoxide (nmol/min/mg protein) |
Carbonyl (nmol/mg protein) |
Complex I/III (nmol/min/mg protein) |
Complex IV (μmol/min/mg protein) |
|---|---|---|---|---|---|
| Liver | Control | N.D. | 3.03 ± 0.10 | 819.8 ± 81.2 | 2050.4 ± 67.9 |
| LoQ | N.D. | 3.09 ± 0.15 | 822.5 ± 85.7 | 2232.5 ± 41.1 | |
| HiQ | N.D. | 3.40 ± 0.26 | 748.8 ± 125.6 | 2280.9 ± 87.5 | |
| Heart | Control | 10.89 ± 0.51 | N.D. | 665.2 ± 4.1 | 10,560.1 ± 1073.3 |
| LoQ | 11.93 ± 0.48 | N.D. | 726.4 ± 27.0 | 14,234.0 ± 1056.5 | |
| HiQ | 11.28 ± 0.39 | N.D. | 939.8 ± 123.7 | 13,112.4 ± 1403.6 | |
| Kidney | Control | 3.70 ± 0.14 | 3.12 ± 0.15 | 1000.7 ± 76.4 | 3086.9 ± 309.1 |
| LoQ | 3.48 ± 0.15 | 2.75 ± 0.11 | 1032.8 ± 80.7 | 3723.3 ± 181.9 | |
| HiQ | 3.34 ± 0.17 | 2.52 ± 0.12 | 1072.9 ± 53.9 | 3587.1 ± 86.1 | |
| Skeletal muscle | Control | 5.02 ± 0.43 | N.D. | 1257.1 ± 53.2 | 3104.8 ± 398.9 |
| LoQ | 5.50 ± 0.23 | N.D. | 1026.6 ± 175.6 | 2744.7 ± 321.7 | |
| HiQ | 5.64 ± 0.38 | N.D. | 1270.1 ± 126.8 | 3167.0 ± 38.7 | |
| Brain | Control | N.D. | 2.59 ± 0.28 | 1735.9 ± 138.1 | 4628.2 ± 64.7 |
| LoQ | N.D. | 2.39 ± 0.22 | 1552.1 ± 249.0 | 4309.4 ± 128.0 | |
| HiQ | N.D. | 2.18 ± 0.18 | 1688.5 ± 135.1 | 4511.3 ± 161.7 |
Mice were fed CoQ10 starting at 3.5 months of age. Data are presented as means ± SE (N = 3–6).
N.D., not determined.