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. 2010 Mar 9;5(3):e9590. doi: 10.1371/journal.pone.0009590

Figure 3. D-GIP1–30 improves islet function and diminishes islet pro-apoptotic protein levels in VDF rats.

Figure 3

A, OGTTs were performed on obese VDF rats ∼24 h prior to and ∼48 h following 10 days of twice daily treatment with PBS or D-GIP1–30 (8 nmol/kg BW) and blood glucose levels measured. Mean ± SEM (n = 6); **, p<0.01 vs same VDF rats prior to treatment. B, Integrated glucose profile for OGTTs described in A. Mean ± SEM (n = 6); significant differences as shown. C, Insulin levels were determined from blood samples collected in A. Mean ± SEM (n = 6); *, p<0.05 vs same VDF rats prior to treatment. B, Integrated acute insulin response (from 0 to 30 minutes) for insulin profiles described in C. Mean ± SEM (n = 6); significant differences as shown. E, Islets were isolated from VDF rats and age matched Lean rats ∼24 h following OGTTs and Western analysis performed on cell lysates with indicated antibodies. F, For quantification, protein levels were normalized to beta-actin and expressed relative to Lean controls. Mean ± SEM (n = 3); $, p<0.05 vs Lean; #, p<0.05 vs VDF controls.