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. 2010 Mar 9;5(3):e9598. doi: 10.1371/journal.pone.0009598

Figure 5. 2P2IDB Server (http://2p2idb.cnrs-mrs.fr).

Figure 5

A: Query procedures to retrieve data stored in the database for each PPI. The database can be searched by family, by PDB codes of the protein/protein complexes, protein/ligand complexes, or unbound proteins, ligand properties or cluster number. A list of PDB codes or Uniprot numbers is returned as well as links to relevant databases. A detailed report of properties of each PPI is also provided. B: Interactive menu to compare user defined PPI properties with the 2P2IDB dataset. The user can enter pre-calculated values for the six key descriptors that were used in the PCA analyses. In return, these parameters are compared to the 2P2IDB dataset and an estimation of the druggability of the target is proposed.