Table 1. Complex families in 2P2IDB.
Class | # | Family | Complexa | Number of Inhibitorsb | Sourcec | Affinityd (nM) | Ref |
I | 1 | BclXL/Bak | 1bxl | 8 | PubMed | 340 | [27] |
I | 2 | MDM2/p53 | 1ycr 1ycq | 3 | PubMed | 600 | [28] |
I | 3 | XIAP BIR3/CASPASE 9 | 1nw9 | 2 | PubMed | 20 | [29] |
I | 4 | XIAP BIR3/SMAC | 1g73 | 5 | PubMed | 420 | [29] |
I | 5 | ZipA/FtsZ | 1f47 | 4 | PubMed | 20,000 | [30] |
II | 6 | Chagasin/Papain | 3e1z | 1 | PDB | 0.036e | [31] |
II | 7 | E2/E1 | 1tue | 1 | PubMed | na | [32] |
II | 8 | FKBP12/TGFR | 1b6c | 17 | PDB | na | [33] |
II | 9 | IL-2/IL-2R | 1z92 | 8 | PubMed | 10 | [34] |
II | 10 | MMP1/TIMP1 | 2j0t | 1 | PDB | 0.40e | [35] |
II | 11 | MMP3/TIMP1 | 1oo9 | 1 | PDB | 0.22e | [36] |
II | 12 | Subtilisin/Eglin C | 1cse 1r0r 1to2 | 1 | PDB | 0.029 | [37]–[39] |
II | 13 | Thrombin/Protein C inhibitor | 3b9f | 1 | PDB | na | [40] |
II | 14 | Trypsin/Trypsin inhibitor | 2uuy | 3 | PDB | 0.02 | [41] |
PPIs were subdivided into class I that correspond to protein/peptide interactions with less than six segments at the interface (families 1–5) and class II that represent more globular interacting domains with more segments (families 6–14).
PDB code of protein/protein complexes.
Number of inhibitors present in the database for a given protein/protein complex.
Structures were retrieved through exhaustive search of the protein databank (PDB) or literature data mining (PubMed).
Dissociation constant (KD) of the protein/protein complexes are indicated in nanomolar when available.
indicates Ki values.