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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Trends Biochem Sci. 2009 Oct 31;35(3):161–168. doi: 10.1016/j.tibs.2009.10.002

Figure 2. Three major models for the regulation of LRP5/6 phosphorylation.

Figure 2

In the direct inhibition model, GSK3 might be directly inhibited by phosphorylated PPP(S/T)P motifs. GSK3 might be recruited in a manner depending on AXIN, which might be recruited by Wnt via FZD and DVL. In the signalosome model, Wnt induces clustering of LRP6, leading to its phosphorylation by CKIγ and subsequently by GSK3 and recruitment of AXIN. PIP2, whose production is stimulated by Wnt via FZD and DVL, is required for the signalosome formation. GPCRs such as PTH1R might interact with LRP6 and regulates LRP6 phosphorylation and AXIN recruitment. Proteins that were identified recently for promoting or inhibiting LRP6 phosphorylation are listed.