Table 2.
Hazard ratios for time to cirrhosis in rapid and slow fibrosers.
| Variable | Unadjusted Hazard Ratio (95% CI) | P Value | Adjusted Hazard Ratio (95% CI)† | P Value |
|---|---|---|---|---|
| Fibrosis Progression | ||||
| Slow | Reference | Reference | ||
| Rapid | 132.30 (17.64-950.73) | < 0.001 | 111.19 (14.64-844.47) | <0.001 |
| Gender | ||||
| Male | Reference | Reference | ||
| Female | 2.40 (1.23-4.66) | 0.010 | 1.15 (0.50-2.65) | 0.736 |
| Recipient Agea | 0.97 (0.94-1.01) | 0.123 | 1.00 (0.95-1.04) | 0.846 |
| Recipient Race | ||||
| White | Reference | |||
| Black | 1.11 (0.52-2.36) | 0.783 | ||
| Other | 1.37 (0.48-3.91) | 0.559 | ||
| Transplant Era | ||||
| 1992-2002 | Reference | Reference | ||
| 2003-2007 | 2.18 (1.09-4.37) | 0.027 | 1.20 (0.50-2.91) | 0.684 |
| Donor Agea | 1.02 (1.00-1.04) | 0.030 | 1.02 (0.99-1.04) | 0.127 |
| Acute Rejection Scoreb | 2.55 (1.38-4.71) | 0.003 | 1.17 (0.56-2.44) | 0.669 |
| Acute Rejection Episodesc | 1.55 (1.15-2.09) | 0.004 | ||
| Chronic Rejectiond | 3.55 (1.87-6.73) | <0.001 | 1.43 (0.65-3.14) | 0.378 |
| Alcohol | 0.74 (0.37-1.48) | 0.399 |
†
Adjusted model includes fibrosis progression, gender, recipient age, transplant era, donor age, rejection score modeled as a time varying covariate and chronic rejection modeled as a dichotomous variable.
a
Hazard ratio corresponds to a one year increase in age.
b
Acute rejection score is modeled as a time varying covariate with the severity of the episode noted at each biopsy being reflected at that time point.
c
Hazard ratio corresponds to a one unit increase in the number of acute rejection episodes.
d
Hazard ratio represents the risk of progression to cirrhosis if a subject ever had chronic rejection noted on a liver biopsy throughout the study period.