Table 2.

Pituitary SRIF receptor subtype expression

		SRIF receptor subtype expression *					Detection method	Tissue studied	Reference
		SSTR1	SSTR2	SSTR3	SSTR4	SSTR5
Fetal pituitary		+	+	+	+	+	A	human	[15]
Adult pituitary		+	+	+	−	+	A, D	Human, rat	[15,113,114]
Normal pituitary cells	GH	5	60	24	18	72	C, D	Rat	[115–117]
	ACTH	n/a	48	n/a	n/a	29	C, D	Rat	[115–117]
	PRL	n/a	18	n/a	n/a	46	C, D	Rat	[115–117]
	TSH	n/a	16	n/a	n/a	28	C, D	Rat	[115–117]
	FSH/LH	n/a	29	n/a	n/a	10	C, D	Rat	[115–117]
Pituitary tumor cell lines	AtT20a	−	+	+	−	+	B	mouse	[9]
	GH3b	+	+	+	+	+	A	rat	[30]
	TtT/GFc	n/a	+	+	−	n/a	B	mouse	[21]
	MMQd	−	+	−	−	−	A	rat	[74]

^*(+) or (−) indicates respective presence or absence of the specific SSTR in the cells indicated. Numbers indicate percentage of cells expressing the receptor.

A: reverse transcription PCR; B: quantitative reverse transcription PCR; C: In situ hybridization; D: Immunohistochemistry

^aCells from mouse pituitary tumor secreting ACTH;

^bCells from rat pituitary tumor secreting GH and PRL;

^cCells from mouse pituitary null (folliculostellate) tumor;

^dCells from rat pituitary tumor secreting PRL.

n/a = not available