. Author manuscript; available in PMC: 2011 Mar 1.

Published in final edited form as: Trends Endocrinol Metab. 2010 Feb 9;21(3):123–133. doi: 10.1016/j.tem.2009.12.003

Table 5.

SRIF regulation of pituitary function

	Relevant pituitary cell process	SRIF effect	Pathways involved	Receptors involved
Pituitary hormones	Hormone synthesis	conflicting result	unknown	SSTR2
	Hormone packaging & trafficking	unknown	N/A	N/A
	Hormone degradation	unknown	N/A	N/A
	Hormone containing vesicle exocytosis	inhibition	Increased K⁺,	SSTR1, 2, 3, 5
			Decreased Ca²⁺,
			Decreased cAMP

Pituitary cell growth	Proliferation	inhibition	Increased PTP	SSTR2, 5
			PI3K/Akt^*
	Apoptosis	stimulation	Increased PTP	SSTR2
			Inhibiting PI3K/Akt
	Senescence	unknown

Conflicting results whether PI3K/Akt is activated or inhibited.