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. Author manuscript; available in PMC: 2010 Oct 15.
Published in final edited form as: Neuron. 2009 Oct 15;64(1):110–122. doi: 10.1016/j.neuron.2009.08.039

Figure 2. Increased microglial activation in the aged brain.

Figure 2

Immunostaining for the endosomal/lysosomal enzyme CD68, a marker of the microglia/macrophage lineage, shows a prominent increase in the neocortex of 24-month-old C57BL/6 mouse (B) compared with a 6-month-old mouse (A) consistent with increased microglial activation in aged brains. Inserts show individual microglia under higher magnification where hypertrophied cell bodies are evident in aged brains (compare insert A to B). Scale bars represent 50µm under 20 or 40× magnification.