Figure 6. The attenuation of the IJP in the ulcerated region does not appear to involve TNBS-induced AH neuron hyperexcitability or facilitation of interneuronal synaptic activity.

A, graph of data from TNBS-treated preparations illustrating that the amplitude of the IJP is not increased by the HCN channel blocker, ZD7288 (10 μm), which should increase the afterhyperpolarization in AH neurons and decrease their excitability. B, graph illustrating that the TNBS colitis-induced attenuation of the evoked IJP is not reversed by inhibition of interneuronal synaptic transmission with 300 μm hexamethonium. *P < 0.002.