TABLE 2.
8 Week (Chow Diet) |
11 Week (+3 Week HF) |
16 Week (+8 Week HF) |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Trait | Chr | cM | LOD | Chr | cM | LOD | Chr | cM | LOD | |||
TG | 1 | 34 | 2.6 | 1 | 34 | 2.6 | 1 | 34 | 4.1 | Tgq9 | ||
2 | 3 | 4.5 | Tgq10 | 2 | 27 | 5.1 | Tgq11 | |||||
2 | 75 | 2.9 | Tgq12a | |||||||||
3 | 18 | 4.7 | Tgq13 | 3 | 41 | 4.8 | Tgq14 | |||||
3 | 71 | 5.2 | Tgq15 | 3 | 73 | 3.9 | ||||||
4 | 45 | 3.5 | Tgq16 | 4 | 24 | 2.9 | ||||||
4 | 68 | 4.4 | Tgq17 | |||||||||
5 | 26 | 3.1 | 5 | 26 | 2.6 | |||||||
7 | 55 | 2.7 | 7 | 53 | 3.5 | |||||||
8 | 40 | 4.5 | Tgq18 | 8 | 41 | 2.7 | 8 | 40 | 2.9 | |||
9 | 11 | 3.7 | 9 | 18 | 4.1 | Tgq19 | 9 | 6 | 4.7 | Tgq19 | ||
10 | 52 | 4.7 | Tgq20 | 10 | 45 | 2.8 | 10 | 60 | 5.5 | Tgq21 | ||
11 | 25 | 4.3 | Tgq22 | 11 | 19 | 5.4 | Tgq22 | |||||
12 | 45 | 5.6 | Tgq23 | 12 | 45 | 3.6 | 12 | 45 | 3.7 | |||
13 | 60 | 3.7 | 13 | 58 | 4.3 | Tgq24 | ||||||
14 | 48 | 4.4 | Tgq25 | 14 | 22 | 3.5 | 14 | 25 | 4.6 | Tgq26 | ||
15 | 31 | 3.8 | Tgq27a | |||||||||
16 | 40 | 3.5 | 16 | 40 | 5.5 | Tgq28 | 16 | 40 | 3.9 | |||
17 | 14 | 3.6 | 17 | 16 | 3.2 | |||||||
18 | 7 | 3.3 | 18 | 17 | 2.5 | |||||||
19 | 51 | 4.8 | Tgq29 | 19 | 51 | 3.3 | 19 | 51 | 2.7 | |||
HDL | 2 | 21 | 3.6 | 2 | 8 | 3.3 | ||||||
3 | 2 | 4.0 | Hdlq61 | |||||||||
4 | 10 | 2.5 | ||||||||||
4 | 60 | 2.5 | 4 | 64 | 2.9 | Hdlq64 | ||||||
9 | 1 | 4.1 | Hdlq62 | |||||||||
10 | 42 | 2.5 | 10 | 37 | 3.3 | |||||||
12 | 45 | 2.5 | Hdlq63 | 12 | 45 | 2.5 | Hdlq63 | |||||
14 | 26 | 2.6 | ||||||||||
16 | 39 | 3.9 | Hdlq65 | 16 | 30 | 2.5 | Hdlq65 |
Chr, chromosome; LOD, logarithm of the odds ratio; TG, triglyceride. The 95% confidence limits for quantitative trait loci (QTLs) are not given, because they are not meaningful in a cross for which the parents are identical for most of the genome. All QTLs are suggestive at >0.37 or significant at >0.95 (given in boldface). Suggestive/significance thresholds (determined after 1,000 permutations) for chow, HF 3 weeks, and HF 8 weeks are 2.2/3.8, 2.3/3.8, and 2.4/4.1 for TG and 2.3/3.9, 2.4/4.0, and 2.6/4.1 for HDL.
Suggestive QTLs on Chr 2@75 and Chr 15@31 cM for TG, and Chr 12@41 and Chr 14@26 cM for HDL were named because they had been previously found in other crosses (see Table 3). QTLs for total cholesterol, body weight, and thyroxine (T4) can be found in supplementary Table II.