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. 2008 Nov;49(11):2402–2413. doi: 10.1194/jlr.M800244-JLR200

TABLE 2.

TG and HDL QTL between DBA/1J and DBA/2J

8 Week (Chow Diet)
11 Week (+3 Week HF)
16 Week (+8 Week HF)
Trait Chr cM LOD Chr cM LOD Chr cM LOD
TG 1 34 2.6 1 34 2.6 1 34 4.1 Tgq9
2 3 4.5 Tgq10 2 27 5.1 Tgq11
2 75 2.9 Tgq12a
3 18 4.7 Tgq13 3 41 4.8 Tgq14
3 71 5.2 Tgq15 3 73 3.9
4 45 3.5 Tgq16 4 24 2.9
4 68 4.4 Tgq17
5 26 3.1 5 26 2.6
7 55 2.7 7 53 3.5
8 40 4.5 Tgq18 8 41 2.7 8 40 2.9
9 11 3.7 9 18 4.1 Tgq19 9 6 4.7 Tgq19
10 52 4.7 Tgq20 10 45 2.8 10 60 5.5 Tgq21
11 25 4.3 Tgq22 11 19 5.4 Tgq22
12 45 5.6 Tgq23 12 45 3.6 12 45 3.7
13 60 3.7 13 58 4.3 Tgq24
14 48 4.4 Tgq25 14 22 3.5 14 25 4.6 Tgq26
15 31 3.8 Tgq27a
16 40 3.5 16 40 5.5 Tgq28 16 40 3.9
17 14 3.6 17 16 3.2
18 7 3.3 18 17 2.5
19 51 4.8 Tgq29 19 51 3.3 19 51 2.7
HDL 2 21 3.6 2 8 3.3
3 2 4.0 Hdlq61
4 10 2.5
4 60 2.5 4 64 2.9 Hdlq64
9 1 4.1 Hdlq62
10 42 2.5 10 37 3.3
12 45 2.5 Hdlq63 12 45 2.5 Hdlq63
14 26 2.6
16 39 3.9 Hdlq65 16 30 2.5 Hdlq65

Chr, chromosome; LOD, logarithm of the odds ratio; TG, triglyceride. The 95% confidence limits for quantitative trait loci (QTLs) are not given, because they are not meaningful in a cross for which the parents are identical for most of the genome. All QTLs are suggestive at >0.37 or significant at >0.95 (given in boldface). Suggestive/significance thresholds (determined after 1,000 permutations) for chow, HF 3 weeks, and HF 8 weeks are 2.2/3.8, 2.3/3.8, and 2.4/4.1 for TG and 2.3/3.9, 2.4/4.0, and 2.6/4.1 for HDL.

a

Suggestive QTLs on Chr 2@75 and Chr 15@31 cM for TG, and Chr 12@41 and Chr 14@26 cM for HDL were named because they had been previously found in other crosses (see Table 3). QTLs for total cholesterol, body weight, and thyroxine (T4) can be found in supplementary Table II.