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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Psychopharmacology (Berl). 2010 Feb 24;209(2):191–202. doi: 10.1007/s00213-010-1789-8

Figure 6.

Figure 6

Effects of the cannabinoid CB1 antagonist rimonabant (Rim) on augmentation of the discriminative effects of THC induced by cocaine (Coc) and quinpirole (Quinp) (A) and effects of a combination of the FAAH inhibitor URB-597 (URB) with quinpirole (Quinp) (B). Ordinates: overall percentage of responses on the lever associated with THC administration (upper panels) and overall rate of lever pressing expressed as responses per seconds (lower panels) averaged over the entire session. Abscissae: dose in mg/kg (log scale). Results represent means±SEM from 10 rats for panel A and 9 rats for panel B. Repeated measures ANOVA followed by post-hoc Dunnet’s test: *: p<0.05 and **: p<0.01 compared to vehicle. Numbers in parentheses at higher doses indicate the number of rats that completed at least one fixed ratio during the session over the total number of rats in which the dose was tested. Dose-response curve data for THC are the same as shown in Fig. 1 and quinpirole data in fig. 6B are the same as shown in fig. 2. In addition, dose-response curve data for THC + Coc and THC + Quinp are the same as in Fig. 1B.