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. 2008 Nov 4;17(1):183–190. doi: 10.1038/mt.2008.229

Figure 2.

Figure 2

eGFP+ MSCs grafted into established N29DsRed tumor migrate along infiltrative tumor extensions and to distant microsatellites. The invasive growth pattern of the N29 tumor resembles that of glioblastoma multiformae. (a) eGFP+ MSCs (green) are mainly located within the main tumor mass but several mesenchymal stroma cells (MSCs) are also found along tumor extensions (arrow) and at distant tumor microsatellites (asterisks) infiltrating into the normal brain parenchyma. Only minimal numbers of grafted eGFP+ MSCs can be found in normal brain tissue adjacent to tumor. Bar = 100 µm. (b) Number of tumor extensions and distant tumor microsatellites infiltrated by eGFP+ MSCs at various time points following MSC grafting into established N29DsRed tumor. Data are shown as mean ± SEM, n = 4–5 animals for each time point. eGFP, enhanced green fluorescent protein.