Figure 5.

Radiation sensitivity of Ku80^−/− mice. (A) Adult (3 months old) agouti wild-type and Ku80^−/− mice were subjected to 300 cGy γ-irradiation, and mice were photographed 2 months after the treatment. Irradiation resulted in the appearance of gray hair in Ku80^−/− mice but did not affect the color coat of wild-type mice. (B) Survival of Ku80^−/− (□) and wild-type (▪) mice subjected to 400 cGy. Six 3-month-old mice from each group were treated simultaneously and then monitored for 2 weeks. Whereas all of the wild-type mice survived, 100% of the Ku80^−/− mice died within this time period.