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. 2008 Dec 23;17(3):516–523. doi: 10.1038/mt.2008.283

Figure 1.

Figure 1

Detection of adeno-associated viral (AAV) particles in the treated retina of P1. (a) Semithin section of the right, injected retina. Bar = 200 µm. (b–e) Ultrathin sections of the right, injected retina at different magnifications. (b) Portion of the retina, where viral particles were found (indicated by an arrow). Bar = 20 µm. (c) Magnification of the area indicated in b. The arrow marks a synaptic ribbon structure. The squares indicate the location of the images in d and e. Bar = 1 µm. (d) Vector particles are found inside of synaptic invaginations. Bar = 200 nm. (e) Vector particles are found outside of synaptic invaginations, within the photoreceptor. Asterisks mark synaptic vesicles with a medium diameter of 50 nm. Bar = 200 nm. The insert represents a magnification to identify the hexagonal structure and the size of the particles of 21 nm. Bar = 100 nm. (f) Ultrathin section of the left, noninjected retina. The arrow marks a synaptic ribbon structure. Asterisks mark synaptic vesicles with a medium diameter of 50 nm. Bar = 200 nm. (g) Schematic representation of the anatomic structures within rod spherule and cone pedicule. GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer (photoreceptor nuclei); IS, inner segments (of photoreceptors); OS, outer segments (of photoreceptors); RPE, retinal pigment epithelium; SR, synaptic ribbon; SI, synaptic invagination.