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Cytosine deaminase (CD) from HB1.F3.CD (F3.CD) cells effectively converts the prodrug 5-fluorocytosine (5-FC) to 5- fluorouracil (5-FU). (a) F3 and F3.CD cells were treated with 0.5 mmol/l 5-FC or 5-FU for 4 days. (b) The cytotoxic effects of 5-FU and 5-FC were quantified by cell viability assays (0–1 mmol/l 5-FC or 5-FU for 48 hours). Each group, n = 4. (c,d) Influences of 5-FC and 5-FU on MDA-MB-435, K1735, and PC14PE6 cells were also checked using the same experimental methods.
