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. 2009 Jan 6;17(3):570–575. doi: 10.1038/mt.2008.290

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Copyright 2009, The American Society of Gene Therapy

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F3.CD cells had little therapeutic effect on large brain metastasis. To test whether F3.CD had therapeutic effects on metastatic brain tumors when the F3.CD and 5-fluorocytosine (5-FC) treatment started after brain metastasis grew large, the treatment was started 1 week later than in the experiment above (Figure 3a). (a) Timeline for the experiment. The therapeutic effect was determined using (b) magnetic resonance imaging (MRI) scans and (c) survival analysis. (b) Some animals treated with F3.CD and 5-FC (group 4) showed mild tumor volume reduction. (c) Survival analysis was performed using the Kaplan–Meier and log rank tests. There was no difference in survival (P = 0.221). Cumulative survival = ratio of survive animal. HBSS, Hanks' balanced salt solution; i.p., intraperitoneal.