Figure 4.
Histology of joints from lentivirus-treated mice with CIA. (a) Destructive arthritis in a knee joint from a mouse injected with LNT-Ii-CLIP viral particles 28 days before CII immunization and killed at day 40 after CII. (b) Nonarthritic and (c) arthritic knee joints from mice injected with LNT-Ii-CII viral particles 28 days before CII immunization and killed at day 40 after CII. (d) Quantification of histological examinations. Box plots represent median and 75th and 95th centile. S = synovia, C = cartilage, B = bone, M = menicus, E = erosions. Scale bar, 50 µm.