Figure 6.

Immunostaining for immune markers in rat brain following an intrastriatal injection of nanoparticles or a sham injection. A single-tract injection of compacted pUL3 (4.1 µg/µl; 4.0 µl) was made into the left striatum; for the control, the injection cannula was lower into the striatum and an equal volume of sterile saline was injected into the site. Arrows point to the location of the injector tract. Low-level expression of the macrophage and microglia marker, ED-1, and the marker for cytotoxic T-cells, OX-8, were identified in brain sections 3 weeks after the injection of nanoparticles; this level of expression was equivalent to the sham-injected site. ac, anterior commissure and scale bar = 500 µm.