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. 2009 Feb 24;17(5):828–836. doi: 10.1038/mt.2009.11

Figure 7.

Figure 7

Transfection efficiency using vectors with clustered and homogeneous ligands. Luciferase transgene expression of DNA/PEI and DNA/PEI-Au-Cap-RGD-ASA compared to DNA/jetPEI and DNA/jetPEI-RGD for (a) high- and (b) low-αvβ3-integrin-expressing HeLa cells (n = 3). Sensitivity of the vector to integrin density can be compared using the transfection efficiency of high- and low-integrin-expressing cells by dividing the RLU/mg of the high-expressing cells to the RLU/mg of the low-expressing cells (integrin sensitivity factor). (c) integrin sensitivity factor comparison of HeLa cells for DNA/PEI, DNA/PEI-Au-Cap-RGD-ASA, DNA/jetPEI, and DNA/jetPEI-RGD (n = 3).