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. 2003 Nov 17;100(24):13881–13886. doi: 10.1073/pnas.2235848100

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Copyright © 2003, The National Academy of Sciences

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Fig. 2. — Free-energy profile for the interaction of INH-NAD with InhA. was calculated for the EI and EI* states by using K_–1 and K_i and applying a standard state of 1 μM. The free energy of the transition state for the conversion of EI to EI* (‡₂) is determined from k₂.(A) Free-energy profile for WT InhA. (B) Free-energy profiles for WT enzyme (heavy line) and M161V (light line, ⋄), and data points for I21V (▿), I47T (○), and S94A (□).

Inline graphic — Free-energy profile for the interaction of INH-NAD with InhA. was calculated for the EI and EI* states by using K_–1 and K_i and applying a standard state of 1 μM. The free energy of the transition state for the conversion of EI to EI* (‡₂) is determined from k₂.(A) Free-energy profile for WT InhA. (B) Free-energy profiles for WT enzyme (heavy line) and M161V (light line, ⋄), and data points for I21V (▿), I47T (○), and S94A (□).