Table 2.

Toxicities^a

Adverse event	Grade 3		Grade 4		Grade 5		Grade 3 or 4
	Number of patients	%	Number of patients	%	Number of patients	%	Number of patients	%
Total toxicities	6	14	7	17	2	5	15	36
Hematologic	6	14	6	14			12	29
Anemia	1	2	–	–			1	2
Neutropenia	5	12	6	14			11	26
Leukopenia	3	7	4	10			7	17
Thrombocytopenia	4	10	4	10			8	19
Non-Hematologic	4	10	4	10	2	5	10	24
Gastrointestinal	4	10	3	7			7	17
Diarrhea	4	10	–	–			4	10
Dehydration	1	2	1	2			2	5
Colitis/typhlitis	–	–	2	5			2	5
Infection	1	2	3	7			4	10
Pulmonary	–	–	2	5			2	5
Pneumonitis/pulm. inf.	–	–	1	2			1	2
ARDS	–	–	1	2			1	2
Thrombosis	1	2	2	5			3	7
Hypotension	1	2	1	2			2	5
ALT	1	2	–	–			1	2
Renal failure	–	–	–	–	1	2	–	–
Cerebral CNS hemorrhage	–	–	–	–	1	2	–	–

ALT alanine transaminase, ARDS acute respiratory distress syndrome, CNS central nervous system, pulm. Inf., pulmonary infiltrates

^aSome patients had more than one type of toxicity, and totals therefore may exceed 42