Figure 6.

Echistatin-displaying measles virus, MV-GEcs, infects endothelial cells of tumor blood vessels postintravenous administration into SCID mice bearing subcutaneous KAS 6/1 human myeloma xenografts. Mice were given 1 x 10⁶ TCID₅₀ of parental MV-GFP virus or MV-GEcs virus. Tumors were harvested 4 days later. Dual staining was performed on the tumor sections using an antibody against measles nucleocapsid (N) protein (red color) and an antibody against murine CD31 (green color). Representative images (×200 magnification) of tumors from different mice are shown. Bar = 20 µm. SCID, severe combined immunodeficiency.